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Research for the Cure

grants awarded

Previously funded grants have included:


UCL Institute of Child Health – $200,000 (December 2015)

Towards T-cell based immunotherapy for DIPG
Grant Information
Thank You Letter

Boston Children’s Hospital – $110,000 (December 2015)

Enabling epigenetic therapies by exploring DIPG chromatin sensitivities
Grant Information

Children’s National Health System and Children’s Research Institute – $125,000 (December 2015)

Comprehensive Molecular‐Based Cross‐Species Comparison of DIPG Biology
Grant Information
Thank You Letter

Baylor College of Medicine/Texas Children’s Hospital – $200,000 (December 2015)

Targeting DIPGs through Super-activation of Steroid Receptor Co-activators: An in vivo Study in Patient-derived Intra-brain Stem Xenograft Mouse Models
Grant Information

Memorial Sloan Kettering Cancer Center – $99,880 (December 2015)

Targeting DIPGs through Super-activation of Steroid Receptor Co-activators: An in vivo Study in Patient-derived Intra-brain Stem Xenograft Mouse Models
Grant Information

Cincinnati Children’s Hospital Medical Center – $100,000 (December 2015)

An early Phase 2 Study of LEE011, a CDK4/6 Inhibitor, following radiation therapy in Children with Newly Diagnosed non-biopsied Diffuse Pontine Gliomas (DIPG) and Rb+ biopsied DIPG and High Grade Gliomas (HGG)
Grant Information
Thank You Letter

Dana-Farber Cancer Institute – $100,000 (December 2015)

Characterizing resistance mechanisms to radiation therapy and adjuvant chemotherapy in Diffuse Intrinsic Pontine Glioma
Grant Information
Thank You Letter

Dana-Farber Cancer Institute – $100,000 (December 2015)

Discovering novel epigenetic dependencies in Diffuse Intrinsic Pontine Glioma
Grant Information
Thank You Letter

Jewish General Hospital – $100,000 (December 2015)

Genetic and Epigenetic Profiling of Diffuse Invasive Pontine Glioma Cells In Vitro
Grant Information
Thank You Letter

Children's Cancer Institute – $144,595

Fenretinide, a novel agent targeting RTK/PI3K/AKT network for the treatment of Diffuse Intrinsic Pontine Glioma.
Grant Information

VU University Medical Center – $92,950 (November 2015)

Liquid Biopsies for the Monitoring of Diffuse Intrinsic Pontine Glioma.
Grant Information
Thank You Letter

Children’s National Hospital – $200,000 (October 2015)

Evaluating TORC1/2 kinase inhibition in murine and nonhuman primate (NHP) models
Grant Information

Sick Kids Hospital – $190,905 (October 2015)

Mitochondrial DNA alterations and their potential as a novel therapeutic target in DIPG
Grant Information

Cincinnati Children's – $200,000 (October 2015)

Intra-tumoral heterogeneity in diffuse intrinsic pontine and midline high-grade gliomas
Grant Information
Thank You Letter

Stanford University – $200,000 (September 2015)

Targeting neuronal activity-regulated DIPG infiltration
Grant Information

Institute of Cancer Research – $99,470 (September 2015)

Evolutionary Dynamics of DIPG
Grant Information

European DIPG Registry - $227,801 (September 2015)


Thank You Letter

International DIPG Registry – $699,935 (August 2015)

Establishement of an International Diffuse Intrinsic Pontine Glioma
Grant Information
Thank You Letter

Ann & Robert H. Lurie Children’s Hospital of Chicago - $50,000 (April 2015)

Increased Tenascin-C (TNC) protein expression in tumor tissue and CSF in DIPG patients
Grant Information

Stanford University Medical Center - $50,000 (April 2015)

Tumor Associated Microglia in Diffuse Intrinsic Pontine Glioma
Grant Information

Cincinnati Children’s Hospital - $100,000 (February 2015)

Epigenetic Alterations As Therapeutic Targets In Pediatric Brain Tumors
Grant Information
Thank You Letter

Lowy Cancer Research Centre (AU) - $81,683.35 (February 2015)

Facilitates Chromatin Transcription Complex (FACT): A novel therapeutic target against Diffuse Intrinsic Pontine Glioma
Grant Information

Cincinnati Children's Hospital - $176,186 (November 2014)

DIPG Registry

University of California, San Francisco - $100,000 (September 2014)

Single-cell profiling and targeting of developmentally regulated signaling programs in DIPG
Grant Information
Thank You Letter

VU University Medical Center - $30,529.68 (September 2014)

European DIPG Registry
Grant Information

The Institute of Cancer Research - $95,325 (September 2014)

The Evolutionary Dynamics of DIPG
Grant Information
Thank You Letter

The Hospital for Sick Children - $99,400 (September 2014)

Development of subgroup-specific models of paediatric DIPG
Grant Information
Thank You Letter

Dana-Farber Cancer Institue - $50,000 (December 2013)

Targeted Therapy of DIPG
Grant Information
Thank You Letter

Cincinnati Children's Hospital Medical Center - $205,000 (November 2013)

Establishment of an International Diffuse Intrinsic Pontine Glioma (DIPG) Registry
Grant Information
Thank You Letter

Yale University School of Medicine - $100,000 (November 2013)

Pre-Clinical Development of Novel DIPG Radiosensitizers
Grant Information
Thank You Letter

The Hospital for Sick Children - $100,000 (November 2013)

Investigating Mechanisms of Therapeutic Resistance in DIPG
Grant Information
Thank You Letter

Duke Children's Hospital - $85,394 (November 2013)

Development of peptide vaccine for diffuse intrinsic pontine glioma
Grant Information
Thank You Letter

Texas Children's Cancer Center - $100,000 (November 2013)

Targeting DIPGs in vivo in Intra-brain Stem Xenograft Mouse Models through Combined Radiation and Oncolytic Viral Therapy
Grant Information
Thank You Letter

Monash Institute of Medical Research - $108,840 (AU) (November 2013)

Targeted Therapy and Stem cell Therapy for DIPG
Grant Information
Thank You Letter

Children's Hospital of Chicago - $100,000 (November 2013)

Ex-vivo expanded natural killer (NK) cells to target DIPG tumor cells in pre-clinical studies
Grant Information
Thank You Letter

Children's National Medical Center - $99,979 (October 2013)

Comparative Proteomic and RNA Sequencing of DIPGs
Grant Information
Thank You Letter

Children's Cancer Institute Australia - $100,000 (January 2013)

Research of treatments for Diffuse Intrinsic Pontine Glioma (DIPG)
Thank You Letter

St. Jude Children's Research Hospital - $15,000 (November 2012)

Establishment and Characterization of Renewable Tissue Resources for Diffuse Intrinsic Pontine Glioma Research
Grant Information
Thank You Letter

Texas Children's Cancer and Hematology Services - $100,000 (November 2012)

Preclinical Evaluation of Novel BMI---1 Inhibitors in vivo in Intra---Brainstem Orthotopic Xenograft Mouse Models
Grant Information
Thank You Letter

Stanford University Medical Center - $35,589 (November 2012)

A Combinatorial Approach to Target Cellular Subpopulations in Diffuse Intrinsic Pontine Glioma.
Grant Information
Thank You Letter

Cincinnati Children's Hospital Medical Center - $219,000 (January 2012)

Establishment of an International DIPG Registry
Grant Information
Thank You Letter

Texas Children's Hospital - $100,000 (November 2011)

Eliminating Therapy–Resistant Diffuse Intrinsic Pontine Gliomas with Oncolytic Picorna Virus SVV-001: an in vivo Study in Intra-brain Stem Xenograft Mouse Models
Grant Information
Thank You Letter

Duke Children's Hospital & Health Center - $82,049 (November 2011)

Preclinical evaluation of systemic and direct delivery of a PDGFR-alpha antibody
Grant Information
Thank You Letter

Doernbecher Children's Hospital - $100,000 (November 2011)

Rapid Preclinical Development of a Targeted Therapy Combination for DIPG
Grant Information
Thank You Letter

Sydney Children's Hospital - $100,000 (August 2011)

Rapid Development of Targeted Therapies
Grant Information
Media Release

St. Jude Children's Research Hospital - $35,000 (September 2010)

Signaling Effectors in Diffuse Intrinsic Potine Glioma (DIPG)
Grant Information
Thank You Letter

Cincinnati Children's Hospital Medical Center - $35,000
(September 2010)

Establishment of a pre-clinical model for prediatric glioblastoma
Grant Information
Thank You Letter

Cincinnati Children’s Hospital Medical Center - $75,000 (March 2010)

Telomerase: A Therapeutic Target in Pediatric Brain Tumors
Grant Information
Thank You Letter

Weill Medical College of Cornell University and Memorial Sloan-Kettering Cancer Hospital - $91,740 (March 2010)

Phase I Study of tumor-targeting Convection-Enhanced Delivery (CED) of radio immunotherapy for Diffuse Pontine Glioma in Children.
Grant Information
Website
Thank You Letter

St. Jude Children’s Research Hospital - $50,000 (July, 2009)

Phase I Study of the combination of Vandetanib and Dasatanib administered during and after radiation therapy in the children with newly diagnosed DIPG.
Grant Information
Website
Thank You Letter

Cincinnati Children’s Hospital Medical Center - $50,000 (July, 2009)

National expansion of the study of Radiotherapy and concurrent Bevacizumab +/- Temozolamide followed by Bevacizumab, Irinotecan +/- Temozolamide in patients with newly diagnosed high grade gliomas and DIPG.
Grant Information
Thank You Letter

St. Jude Children’s Research Hospital - $10,000 (July, 2009)
(in association with Smiles for Sophie Forever)

Second phase of genetic analysis of DIPG.
Grant Information
Thank You Letter

Cincinnati Children’s Hospital Medical Center - $50,000
(September, 2008)

Study of Radiotherapy and concurrent Bevacizumab +/- Temozolamide followed by Bevacizumab, Irinotecan +/- Temozolamide in patients with newly diagnosed high grade gliomas and DIPG.
Grant Information

St. Jude Children’s Research Hospital - $25,000 (September, 2008)

A multi-institutional study in which an extensive analysis of the genetic make-up of brainstem gliomas will be performed to gain a better understanding of the underlying genetic abnormalities.
Grant Information
Thank You Letter
Prospective Collection of Tissue Samples
at Autopsy Effectiveness
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