NEWS ABOUT THE CURE
The Cure Starts Now Raises Over $500,000 for Pediatric Brain Cancer Research During Annual Giving First Campaign
November 15, 2022
Cincinnati, OH | Nov 15 - The Cure Starts Now Foundation headquartered in Cincinnati, OH with 39 chapters around the world showcases their innovative ways once again with their GIVING FIRST efforts. “GIVING FIRST is our effort to highlight the need to put our kids first because they don’t deserve the leftovers of Holiday shopping. Currently Giving Tuesday is scheduled for Tuesday November 29. This is after Black Friday, Small Business Saturday, and Cyber Monday. As a society we value our kids…
Research Update: The intrinsic and microenvironmental features of diffuse midline glioma: Implications for the development of effective immunotherapeutic treatment strategies
September 21, 2022
Neuro-Oncology
The following study was funded in part by the DIPG/DMG Collaborative and The Cure Starts Now: Abstract Diffuse midline glioma (DMG), including those of the brainstem (diffuse intrinsic pontine glioma), are pediatric tumors of the central nervous system (CNS). Recognized as the most lethal of all childhood cancers, palliative radiotherapy remains the only proven treatment option, however, even for those that respond, survival is only temporarily extended. DMG harbor an immunologically “cold”…
Research Update: Volumetric endpoints in diffuse intrinsic pontine glioma: comparison to cross-sectional measures and outcome correlations in the International DIPG/DMG Registry
September 21, 2022
Neuro-Oncology
The following study was funded in part by the DIPG/DMG Collaborative and The Cure Starts Now: Background Cross-sectional tumor measures are traditional clinical trial endpoints; however volumetric measures may better assess tumor growth. We determined the correlation and compared the prognostic impact of cross-sectional and volumetric measures of progressive disease (PD) among patients with DIPG. Methods Imaging and clinical data were abstracted from the International DIPG Registry. Tumor…
Research Update: Serial H3K27M cell-free tumor DNA (cf-tDNA) tracking predicts ONC201 treatment response and progression in diffuse midline glioma
August 16, 2022
Neuro-Oncology
The following study was funded in part by the DIPG/DMG Collaborative and The Cure Starts Now: Abstract Diffuse Midline Glioma (DMG) with the H3K27M mutation is a lethal childhood brain cancer, with patients rarely surviving 2 years from diagnosis. Methods We conducted a multi-site Phase 1 trial of the imipridone ONC201 for children with H3K27M-mutant glioma (NCT03416530). Patients enrolled on Arm D of the trial ( n = 24) underwent serial lumbar puncture for cell-free tumor DNA (cf-tDNA)…
Research Update: Dual IGF1R/IR inhibitors in combination with GD2-CAR T-cells display a potent anti-tumor activity in diffuse midline glioma H3K27M-mutant
July 27, 2022
Neuro-Oncology
Background Diffuse midline gliomas (DMG) H3K27M-mutant, including diffuse intrinsic pontine glioma (DIPG), are pediatric brain tumors associated with grim prognosis. Although GD2-CAR T-cells demonstrated significant anti-tumor activity against DMG H3K27M-mutant in vivo, a multimodal approach may be needed to more effectively treat patients. We investigated GD2 expression in DMG/DIPG and other pediatric high-grade gliomas (pHGG) and sought to identify chemical compounds that would enhance…
Research Update: Use of Imaging Mass Cytometry in Studies of the Tissue Microenvironment
July 19, 2022
Springer Link
In 2019 Dr. Mara Vinci of Bambino Gesu Children's Hospital proposed an study demonstrating using imaging mass cytometry to identify next generation imaging biomarkers in PHGG and DIPG. This project was approved for funding by the The Cure Starts Now and here are the results: Lay Summary of Proposal The field of pediatric neuro-oncology has been greatly advanced by recent studies, which have better outlined the spectrum of pediatric Central Nervous System (CNS) tumors, into more clearly distinct…
Research Update: Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma
June 29, 2022
Neuro-Oncology
In 2019 Dr. Carl Koschmann of University of Michigan Hospitals proposed an study demonstrating the Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma . This project was approved for funding by the DIPG/DMG Collaborative and The Cure Starts Now and here are the results: Abstract Diffuse midline gliomas (DMG) are highly invasive brain tumors with rare survival beyond two years past diagnosis and limited understanding of the mechanism behind tumor invasion. Previous…
Brain Tumor Awareness Month - Go Gray in May
April 26, 2022
May is "Brain Tumor Awareness Month," a time to recognize and honor those who have been affected by all types of brain cancer while fundraising to support current and ongoing research to make brain cancer a thing of the past. Gray matter is a major component of the central nervous system in the brain, which is part of why the ribbon color for the month of May is gray. This year, The Cure Starts Now invites you to be a ray of hope among all of the gray and take action in the fight against brain…
Zips Esports at The University of Akron partners with The Cure Starts Now to “Nerf” Cancer!
April 13, 2022
Akron, OH | April, 2022 – The University of Akron’s Zips Esports program has partnered with Ohio-based charity, The Cure Starts Now, to host a fundraising event for video gamers to raise money for pediatric brain cancer research. During the 8-hour gaming fundraiser, participating University of Akron students will have the opportunity to play video games throughout the day and fundraise for a crucial cause. The funds raised will benefit pediatric brain cancer research through The Cure Starts…
9th Annual Sydney's Band of Gold Golf Tournament Aims to Raise Funds for Pediatric Brain Cancer Research
April 6, 2022
The North Texas Chapter of The Cure Starts Now has raised over $1.4 million since inception! Grapevine, TX | April 6, 2022 – The North Texas Chapter of The Cure Starts Now is hosting it’s 9 th Annual Sydney’s Band of Gold Golf Tournament in honor or Sydney Bjornberg, a little girl who battled DIPG (Diffuse Intrinsic Pontine Glioma), a brain tumor that is highly aggressive and difficult to treat. The golf outing is being held on April 11, 2022 at the Cowboys Golf Club, the first and only…
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